Lubiprostone (trade name Amitiza) is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. Lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. Lubiprostone has been approved by the U.S Food and Drug Administration on January 31, 2006.


Product Name:                  Lubiprostone

Synonyms:                         RU-0211; SPI-0211

CAS Number:                     136790-76-6

Molecular Weight:            390.4666

Molecular Formula:          C20H32F2O5

Purity (HPLC):                     ≥95%

Shipping Conditions:         Room temperature.

Storage Conditions:           Refrigerated.

Regulatory Statement:      For Research Use Only.

SMILES:                               CCCCC(F)([C@]1(O)O[C@@](CC([C@@H]2CCCCCCC(O)=O)=O)([H])[C@]2([H])CC1)F


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