Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate

Intermediate for Lubiprostone. Lubiprostone (trade name Amitiza) is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. Lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. Lubiprostone has been approved by the U.S Food and Drug Administration on January 31, 2006.


Product Name:                  Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate

Synonyms:                         N/A

CAS Number:                     50889-46-8

Molecular Weight:            258.20146

Molecular Formula:          C9H17F2O4P

Purity (HPLC):                     ≥95%

Shipping Conditions:         Room temperature.

Storage Conditions:           Refrigerated.

Regulatory Statement:      For Research Use Only.

SMILES:                               CCCCC(C(=O)CP(=O)(OC)OC)(F)F

Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate

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