Intermediate for Lubiprostone. Lubiprostone (trade name Amitiza) is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. Lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. Lubiprostone has been approved by the U.S Food and Drug Administration on January 31, 2006.


Product Name:                  (3aR,4S,5R,6aS)-5-Hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

Synonyms:                         N/A

CAS Number:                     32233-40-2

Molecular Weight:            172.1804

Molecular Formula:          C8H12O4

Purity (HPLC):                     ≥95%

Shipping Conditions:         Room temperature.

Storage Conditions:           Refrigerated.

Regulatory Statement:      For Research Use Only.

SMILES:                               O=C2C[C@@H]1[C@@H](CO)[C@H](O)C[C@@H]1O2


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