(4-Carboxybutyl)triphenylphosphonium bromide

Intermediate for Lubiprostone. Lubiprostone (trade name Amitiza) is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. Lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. Lubiprostone has been approved by the U.S Food and Drug Administration on January 31, 2006.


Product Name:                  (4-Carboxybutyl)triphenylphosphonium bromide

Synonyms:                         N/A

CAS Number:                     17814-85-6

Molecular Weight:            443.31916

Molecular Formula:          C23H24BrO2P

Purity (HPLC):                     ≥95%

Shipping Conditions:         Room temperature.

Storage Conditions:           Refrigerated.

Regulatory Statement:      For Research Use Only.

SMILES:                               OC(=O)CCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-]

(4-Carboxybutyl)triphenylphosphonium bromide

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