4-Aminophthalic acid

4-Aminophthalic acid

Intermediate for Apremilast. Apremilast (trade name: Otezla) is a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4) and inhibits spontaneous production of TNF-alpha from human rheumatoid synovial cells. Apremilast is usded for the treatment of certain types of psoriasis and psoriatic arthritis. It may also be useful for other immune system related inflammatory diseases. Apremilast has been approved by the U.S Food and Drug Administration on May 21, 2014.


Product Name:                  4-Aminophthalic acid

Synonyms:                         N/A

CAS Number:                     5434-20-8

Molecular Weight:            181.1476

Molecular Formula:          C8H7NO4

Purity (HPLC):                     ≥95%

Shipping Conditions:         Room temperature.

Storage Conditions:           Refrigerated.

Regulatory Statement:      For Research Use Only.

SMILES:                               OC(=O)c1c(N)cccc1C(=O)O

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