trans-4-Dimethylaminocrotonic acid hydrochloride

Intermediate for Afatinib. Afatinib (trade name: Gilotrif) is an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and erbB-2 (HER2) for the treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC). Afatinib has been approved by the U.S Food and Drug Administration on July 12, 2013.


Product Name:                  trans-4-Dimethylaminocrotonic acid hydrochloride

Synonyms:                         N/A

CAS Number:                     848133-35-7

Molecular Weight:            165.6193

Molecular Formula:          C6H12ClNO2

Purity (HPLC):                     ≥95%

Shipping Conditions:         Room temperature.

Storage Conditions:           Refrigerated.

Regulatory Statement:      For Research Use Only.

SMILES:                               CN(C/C=C/C(=O)O)C.Cl

trans-4-Dimethylaminocrotonic acid hydrochloride

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