6-Nitro-7-Chloro-4-HydroxyQuinazoline

Intermediate for Afatinib. Afatinib (trade name: Gilotrif) is an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and erbB-2 (HER2) for the treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC). Afatinib has been approved by the U.S Food and Drug Administration on July 12, 2013.

Specifications

Product Name:                  6-Nitro-7-Chloro-4-HydroxyQuinazoline

Synonyms:                         N/A

CAS Number:                     53449-14-2

Molecular Weight:            225.5909

Molecular Formula:          C8H4ClN3O3

Purity (HPLC):                     ≥95%

Shipping Conditions:         Room temperature.

Storage Conditions:           Refrigerated.

Regulatory Statement:      For Research Use Only.

SMILES:                               [O-][N+](=O)c1cc2c(=O)[nH]cnc2cc1Cl

6-Nitro-7-Chloro-4-HydroxyQuinazoline

  • $138.00
  • Ex Tax: $138.00

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