7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine

Intermediate for Afatinib. Afatinib (trade name: Gilotrif) is an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and erbB-2 (HER2) for the treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC). Afatinib has been approved by the U.S Food and Drug Administration on July 12, 2013.

Specifications

Product Name:                  7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine

Synonyms:                         N/A

CAS Number:                     179552-73-9

Molecular Weight:            353.1393

Molecular Formula:          C14H7Cl2FN4O2

Purity (HPLC):                     ≥95%

Shipping Conditions:         Room temperature.

Storage Conditions:           Refrigerated.

Regulatory Statement:      For Research Use Only.

SMILES:                               [O-][N+](=O)c1cc2c(ncnc2cc1Cl)Nc1ccc(c(c1)Cl)F

7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine

  • $207.00
  • Ex Tax: $207.00

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