Trametiglue acts as molecular glue. Trametiglue combines the potency and off-rate kinetics of trametinib on KSR-bound MEK with the functional ability of CH5126766 to promote, and potentially trap, inactive states of RAF-bound MEK.
| Product Name | Trametiglue |
| Synonyms | |
| CAS Number | 2666940-97-0 |
| Related CAS | |
| Molecular Formula | C25H24FIN6O5S |
| Molecular Weight | 666.47 |
| SMILES | CNS(=O)(=O)NC1=CC=CC(=C1)N1C(=O)N(C2CC2)C(=O)C2=C(NC3=C(F)C=C(I)C=C3)N(C)C(=O)C(C)=C12 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Khan, Z. M., Real, A. M., Marsiglia, W. M., Chow, A., Duffy, M. E., Yerabolu, J. R., Scopton, A. P.,Dar, A. C., Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature 2020, 588, 509-514.https://doi.org/10.1038/s41586-020-2760-4
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